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Description

Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum

Due to the rotenone-insensitive status of Nde1p and Nde2P, they cannot pump protons (Fedoseeva et al., 2017)

The observed effect of DPI2 was comparable to that of erastin, indicating that DPI2 might trigger cellular ferroptosis via a mechanism analogous to that employed by erastin ( Sorafenib, a multikinase inhibitor, has gained widespread use in the treatment of clinically advanced hepatocellular carcinoma, offering patients prolonged survival